An efficient deprotection of N-trimethylsilylethoxymethyl (SEM) groups from dinucleosides and dinucleotides.

نویسندگان

  • Tilak Chandra
  • William E Broderick
  • Joan B Broderick
چکیده

A convenient and efficient method for deprotection of N-(trimethyl)silylethoxymethyl (SEM) groups from thymidine dinucleoside and dinucleotide has been achieved. The SEM groups were easily removed in excellent yields from protected nucleosides, dinucleosides, and dinucleotides.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Ammonium Decatungstocerate(IV): An Efficient Catalyst for the Protection and Deprotection of Tetrahydropyranyl Ethers

In multi-step organic syntheses, the protection and deprotection of tetrahydropyranyl (THP) ethers is one of the most frequently used methods. Over the years, different methods have been used from various catalytic systems for the protection of hydroxyl groups as THP ethers and their deprotection. Herein we have reported that various alcohols and phenols have been efficiently converted to the c...

متن کامل

A Facile and Environmental Friendly Method for C=N Bond Cleavage of Imines Using p-Toluenesulfonic Acid in Solid State

A simple, efficient and clean procedure has been developed for the cleavage of imines C=N bond. Deprotection of imines to their parent carbonyl and amine compounds was achieved using p-toluenesulfonic acid in the solid state condition at 25-45 ˚C. The salient features of this methodology are shorter reaction times, cheap processing, high yields of product and easy availability of the catalyst. ...

متن کامل

Cerium(IV) as Ceric Triethylammonium Nitrate: An Efficient Catalyst for Protection and Deprotection of Alcohols with Dihydropyran

Catalytic amount of Ce(IV) as ceric triethylammonium nitrate (CTEAN) in dichloromethane or acetone can bring about an efficient tetrahydropyranylation of different types of alcohols to afford the corrsesponding tetrahydropyranyl ethers in high yields. Deportection of tetrahydropyranyl ethers can also be achieved efficiently in the presence of this catalyst in methanol.

متن کامل

Efficient Synthesis and Deprotection of Semicarbazones under Solvent-Free Conditions

Effective methodologies for efficient preparation of semicarbazones from aldehydes or ketones via milling and the subsequent regeneration of the parent carbonyls by gaseous nitrogen dioxide are described under solid-solid and gas-solid reaction conditions, respectively. These methods are fast, simple and environmentally benign which do not require the use of any auxiliaries such as catalyst...

متن کامل

A Rapid and Practical Method for Deprotection of 1,1-Diacetates Catalyzed by Zirconium Sulfate Tetrahydrate-Silica Gel

A simple and efficient procedure for converting a variety of 1,1-diacetates into the corresponding aldehydes was developed. The methodology has been done with zirconium sulfate tetrahydrate-silica gel as catalyst. The temperature plays an important role in these reactions. The phenolic acetate function can selectively be deprotected into phenol.

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Nucleosides, nucleotides & nucleic acids

دوره 29 2  شماره 

صفحات  -

تاریخ انتشار 2010